Proteoglycans of developing bone.

Regulation of Bone Stem Cells by Small Proteoglycans

Differential roles for small leucine-rich proteoglycans in bone formation.

This paper reviews our current state of knowledge of the roles the small leucine-rich proteoglycans (SLRPs) play in the formation of connective tissue and mineralised tissue matrices. Both, the SLRPs biglycan and decorin are highly expressed in extracellular bone matrix and there is now substantial evidence to support an increasing role for biglycan and decorin in influencing bone cell differen...

BONE MARROW FIBROSIS DEVELOPiNG IN

By H. E. TAYLOR, M.D. AND W. W. SIMPsoN, M.D. M ARROW fibrosis is a disease entity characterized by fibrous tissue replacement of the bone marrow with or without varying degrees of bony sclerosis; there is an associated leuko-erythroblastic anemia and usually hepatosplenomegaly is prominent, due to extramedullary hematopoiesis in which megakaryocytes are frequently numerous. This condition pres...

Spatiotemporal distribution of proteoglycans in the developing rat's barrel field and the effects of early deafferentation.

The isolectin Vicia villosa B(4) (VV) selectively recognizes N-acetyl-galactosamine-terminal glycoconjugates that form perineuronal nets (PNNs) around a subset of neurons in the cerebral cortex. PNNs are thought to participate in the guidance of incoming thalamic axons and in the posterior stabilization and maintenance of synaptic contacts. Here we examine the spatial and temporal distribution ...

Spatiotemporal distribution of chondroitin sulfate proteoglycans in the developing mouse retina and optic nerve.

The aim of the present study was to determine the distribution of chondroitin sulfate proteoglycans in the mouse retina and optic nerve of the prenatal and postnatal mouse by immunohistochemistry. At embryonic day (E) 18, chondroitin-4-sulfate (C4S), chondroitin-6-sulfate (C6S) and biglycan were detected in the retina and optic nerve. However, aggrecan was seen in the retina but not in the opti...